Ford C N, Martin D W, Warner T F
Laryngoscope. 1984 Apr;94(4):513-8. doi: 10.1288/00005537-198404000-00016.
Glottic insufficiency has been successfully managed by Teflon augmentation of paretic vocal cords over the past two decades. Collagen fulfills the criteria for a suitable bioimplant and is an attractive alternative as it is a normal constituent of the extracellular protein matrix. This study explores the use of modified bovine collagen injected into the canine larynx. Clinical situations are simulated by creating lesions and injecting collagen at different sites. The technique permits precise placement and quantification. Histologic study of the collagen implant fails to show evidence of significant foreign body reaction. The injected collagen appears similar to viable connective tissue and is colonized by host fibroblasts and nourishing capillaries.
在过去二十年中，通过用特氟隆增大麻痹声带，声门功能不全已得到成功治疗。胶原蛋白符合合适生物植入物的标准，并且作为细胞外蛋白质基质的正常成分，它是一种有吸引力的替代品。本研究探讨了将改良的牛胶原蛋白注入犬喉的应用。通过在不同部位制造病变并注射胶原蛋白来模拟临床情况。该技术允许精确放置和定量。对胶原蛋白植入物的组织学研究未显示出明显异物反应的证据。注入的胶原蛋白看起来与活的结缔组织相似，并被宿主成纤维细胞和滋养毛细血管所占据。
