幼年特发性关节炎患者发生糖尿病的风险。
Risk of Diabetes Mellitus in Patients with Juvenile Idiopathic Arthritis.
机构信息
From the Division of Pharmacoepidemiology and Pharmacoeconomics, and Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Division of Immunology, and Department of Rheumatology, Boston Children's Hospital, Boston, Massachusetts, USA.
Supported by an investigator-initiated research grant from Bristol-Myers-Squibb. Dr. Kim has received research grants from the Brigham and Women's Hospital from Pfizer and Roche for unrelated topics.
出版信息
J Rheumatol. 2020 Sep 1;47(9):1405-1408. doi: 10.3899/jrheum.190644. Epub 2019 Dec 1.
OBJECTIVE
To examine the risk of type 1 diabetes (T1D) associated with juvenile idiopathic arthritis (JIA).
METHODS
Using the IBM MarketScan database, we compared JIA patients with asthma patients and healthy individuals for the risk of incident T1D.
RESULTS
We included patients with 15,210 JIA, 76,050 patients with asthma, and 76,050 healthy individuals matched 1:5 on age, sex, and index date. After adjustment for confounders, the multivariable HR of T1D associated with JIA was 1.48 (95% CI 0.86-2.56) versus asthma and 1.81 (95% CI 1.03-3.17) versus healthy individuals.
CONCLUSION
JIA appears to be associated with an increased risk of T1D compared to patients with asthma and healthy children.
目的
探讨幼年特发性关节炎（JIA）与 1 型糖尿病（T1D）风险的相关性。
方法
我们使用 IBM MarketScan 数据库，比较了 JIA 患者与哮喘患者和健康个体发生 T1D 的风险。
结果
我们纳入了 15210 例 JIA 患者、76050 例哮喘患者和 76050 名年龄、性别和索引日期相匹配的健康个体。在调整了混杂因素后，JIA 与 T1D 的多变量 HR 为 1.48（95%CI 0.86-2.56）与哮喘患者相比，1.81（95%CI 1.03-3.17）与健康个体相比。
结论
与哮喘患者和健康儿童相比，JIA 似乎与 T1D 风险增加相关。
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