Watanabe Takaki, Suzuki Honoka, Kano Masanobu
Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo.
Brain Nerve. 2019 Dec;71(12):1373-1383. doi: 10.11477/mf.1416201457.
Prof. Masao Ito contributed greatly to the elucidation of the structure and function of cerebellar neuronal circuits. He formulated a cerebellar motor learning theory and an internal model hypothesis and pursued how complex cerebellar functions resulted from the operation of neural circuits. In this article, we first provide a brief overview of the major cell types and the synaptic organization of cerebellar neural circuits. Then we introduce how mature cerebellar neural circuits are shaped through synapse formation and pruning during postnatal development. We also refer to the maturation of inhibitory neurons and glial cells during postnatal development.
伊藤正雄教授对阐明小脑神经回路的结构和功能做出了巨大贡献。他提出了小脑运动学习理论和内部模型假说，并探究了神经回路的运作如何产生复杂的小脑功能。在本文中，我们首先简要概述小脑神经回路的主要细胞类型和突触组织。然后我们介绍在出生后发育过程中，成熟的小脑神经回路是如何通过突触形成和修剪而形成的。我们还会提及出生后发育过程中抑制性神经元和神经胶质细胞的成熟。
