Morimoto Koji
College of Pharmaceutical Sciences, Ritsumeikan University.
Research Organization of Science and Technology, Ritsumeikan University.
Chem Pharm Bull (Tokyo). 2019;67(12):1259-1270. doi: 10.1248/cpb.c19-00286.
The biary unit having heteroatom as important scaffolds widely exist in a large number of biologically active compounds and functional organic molecules. Since the cross-coupling is a useful synthetic method for constructing biaryl and heterobiaryl structures, the development of novel cross-coupling methods has been studied intensively. The oxidative biaryl coupling reaction of aromatic compounds having heteroatoms is an attractive method since they do not require the prefunctionalization of arenes. This report describes recent advances in hypervalent iodine(III) induced metal-free synthesis of biaryls having heteroatoms.
以杂原子为重要骨架的联芳基单元广泛存在于大量生物活性化合物和功能性有机分子中。由于交叉偶联是构建联芳基和杂联芳基结构的一种有用的合成方法，因此新型交叉偶联方法的开发受到了广泛研究。具有杂原子的芳香族化合物的氧化联芳基偶联反应是一种有吸引力的方法，因为它们不需要芳烃的预官能化。本报告描述了高价碘（III）诱导的无金属合成含杂原子联芳基的最新进展。
