用卡巴胆碱刺激豚鼠肠纵行平滑肌时肌醇磷酸代谢的早期事件。
Early events in inositol phosphate metabolism in longitudinal smooth muscle from guinea-pig intestine stimulated with carbachol.
作者信息
Salmon D M, Bolton T B
机构信息
Department of Pharmacology, St. George's Hospital Medical School, London, U.K.
出版信息
Biochem J. 1988 Sep 1;254(2):553-7. doi: 10.1042/bj2540553.
Abstract
In longitudinal smooth muscle from guinea-pig intestine prelabelled with [3H]inositol, carbachol produced a 3-fold increase in [3H]inositol 1,4,5-trisphosphate within 2 s, and there was also a simultaneous increase in [3H]inositol 1,4-bisphosphate. 3H-labelling of inositol 1,3,4,5-tetrakisphosphate was not significantly increased until 60 s after carbachol stimulation, and the accumulation of [3H]inositol 1,3,4-trisphosphate was relatively small.
摘要
在预先用[3H]肌醇标记的豚鼠肠道纵行平滑肌中，卡巴胆碱在2秒内使[3H]肌醇1,4,5-三磷酸增加了3倍，同时[3H]肌醇1,4-二磷酸也有增加。直到卡巴胆碱刺激60秒后，肌醇1,3,4,5-四磷酸的3H标记才显著增加，且[3H]肌醇1,3,4-三磷酸的积累相对较少。
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