通过广泛基因分型阐明的未解决的严重慢性鼻窦炎
Unsolved severe chronic rhinosinusitis elucidated by extensive genotyping.
作者信息
Degrugillier Fanny, Simon Stéphanie, Aissat Abdel, Remus Natascha, Mekki Chadia, Decrouy Xavier, Hatton Aurélie, Hinzpeter Alexandre, Hoffmann Brice, Sermet-Gaudelus Isabelle, Callebaut Isabelle, Fanen Pascale, Prulière-Escabasse Virginie
机构信息
INSERM U955 IMRB, Team 5 Créteil France.
DHU Ageing Thorax Vessel Blood Créteil France.
出版信息
Clin Case Rep. 2019 Sep 27;7(11):2128-2134. doi: 10.1002/ccr3.2443. eCollection 2019 Nov.
Severe chronic rhinosinusitis in children should alert clinicians and extensive genotyping should be performed. We propose that thorough clinical and functional assessment in severe chronic rhinosinusitis is valuable to discover rare mutations which could be treated by CFTR correctors to postpone pulmonary infection.
儿童严重慢性鼻-鼻窦炎应引起临床医生的警惕，应进行广泛的基因分型。我们认为，对严重慢性鼻-鼻窦炎进行全面的临床和功能评估，对于发现可通过CFTR校正剂治疗以延缓肺部感染的罕见突变具有重要价值。
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