去甲肾上腺素在治疗三环类抗抑郁药过量所致循环性休克中的有益作用。

Beneficial effect of norepinephrine in the treatment of circulatory shock caused by tricyclic antidepressant overdose.

作者信息

Teba L, Schiebel F, Dedhia H V, Lazzell V A

机构信息

Department of Anesthesiology, West Virginia University Medical Center, School of Medicine, Morgantown 26506.

出版信息

Am J Emerg Med. 1988 Nov;6(6):566-8. doi: 10.1016/0735-6757(88)90092-7.

DOI:10.1016/0735-6757(88)90092-7

PMID:3178947

Abstract

The beneficial effect of dopamine in circulatory shock induced by tricyclic antidepressants (TCA) overdose may be decreased due to compromise of the endogenous stores of norepinephrine caused by TCA. The successful outcome of two cases of TCA overdose complicated by hypotension, unresponsive to an initial treatment with physostigmine fluid challenge and dopamine (greater than 15 micrograms/kg/min) but subsequently responsive to an infusion of norepinephrine is reported.

摘要

三环类抗抑郁药（TCA）过量引起的循环性休克中，多巴胺的有益作用可能会因TCA导致的内源性去甲肾上腺素储备受损而降低。本文报告了两例TCA过量并发低血压的病例，最初使用毒扁豆碱补液试验和多巴胺（大于15微克/千克/分钟）治疗无效，但随后输注去甲肾上腺素后病情好转。