Yamakawa Masahiko, Tachibana Atsumichi, Tatsumoto Muneto, Okajima Katsunori, Ueda Shuichi, Hirata Koichi
Graduate School of Environment and Information Sciences, Yokohama National University, Kanagawa, Japan.
Department of Histology & Neurobiology, Dokkyo Medical University, Tochigi, Japan.
Neurosci Res. 2020 Nov;160:57-64. doi: 10.1016/j.neures.2019.11.011. Epub 2019 Nov 29.
To clarify whether photoreception of intrinsically photosensitive retinal ganglion cells (ipRGCs) is related to migraine, we investigated the relationship between hemodynamic responses related to neural activity and visual stimulation of ipRGCs. It has been established that photoreception in ipRGCs is associated with photophobia in migraine. However, the relationship between visual stimulation of ipRGCs and hemodynamic responses in the visual cortex has not been clarified. Hemodynamic responses in the visual cortex were measured using functional near-infrared spectroscopy (fNIRS) as signals reflecting changes in oxygenated and deoxygenated hemoglobin concentrations. Different types of visual stimulation generated by a metamerism method were applied to the peripheral field of the eye of patients with migraine (N = 20) and healthy participants (N = 21). The stimulation intensity on the retina was controlled using an artificial pupil. In the primary visual cortex of patients with migraine, statistically significant changes in fNIRS signals dependent on visual stimulation intensity applied to ipRGCs were observed (p < 0.01), while no such changes were observed in healthy participants. These results reveal that visual stimulation of ipRGCs projecting to the primary visual cortex is involved in hemodynamic responses in patients with migraine, suggesting that ipRGCs, in addition to photometric values related to cones, are associated with migraine.
为了阐明内在光敏性视网膜神经节细胞（ipRGCs）的光感受是否与偏头痛有关，我们研究了与神经活动相关的血流动力学反应和ipRGCs视觉刺激之间的关系。已经确定，ipRGCs中的光感受与偏头痛中的畏光有关。然而，ipRGCs的视觉刺激与视觉皮层血流动力学反应之间的关系尚未阐明。使用功能近红外光谱（fNIRS）测量视觉皮层的血流动力学反应，作为反映氧合血红蛋白和脱氧血红蛋白浓度变化的信号。通过同色异谱法产生的不同类型的视觉刺激应用于偏头痛患者（N = 20）和健康参与者（N = 21）眼睛的周边视野。使用人工瞳孔控制视网膜上的刺激强度。在偏头痛患者的初级视觉皮层中，观察到fNIRS信号随应用于ipRGCs的视觉刺激强度有统计学意义的变化（p < 0.01），而在健康参与者中未观察到此类变化。这些结果表明，投射到初级视觉皮层的ipRGCs的视觉刺激参与了偏头痛患者的血流动力学反应，这表明ipRGCs除了与视锥细胞相关的光度值外，还与偏头痛有关。
