Hausdorf G, Siglow V, Nienaber C A
Department of Cardiology, University of Hamburg, West Germany.
Br Heart J. 1988 Sep;60(3):240-6. doi: 10.1136/hrt.60.3.240.
The effects of increasing afterload on early diastolic dysfunction in 10 patients with hypertrophic non-obstructive cardiomyopathy were studied by computer assisted analyses of digitised M mode echocardiograms. Infusion of angiotensin II increased the end systolic pressure by a mean (SD) of 36.2 (10.3) mm Hg. As the afterload increased early diastolic dysfunction tended to become more normal: the interval and the change in dimension between minimal cavity dimension and mitral valve opening decreased and the duration of rapid diastolic filling and the accompanying change in dimension increased. None the less, the end diastolic dimension and thus the overall diastolic filling remained unchanged. Impaired early diastolic function in hypertrophic cardiomyopathy is at least partly caused by altered loading conditions.
通过对10例肥厚型非梗阻性心肌病患者数字化M型超声心动图进行计算机辅助分析，研究了后负荷增加对早期舒张功能障碍的影响。输注血管紧张素II使收缩末期压力平均（标准差）升高36.2（10.3）mmHg。随着后负荷增加，早期舒张功能障碍趋于变得更正常：最小腔径与二尖瓣开放之间的时间间隔和径线变化减小，快速舒张期充盈持续时间及伴随的径线变化增加。尽管如此，舒张末期径线以及整体舒张期充盈仍保持不变。肥厚型心肌病早期舒张功能受损至少部分是由负荷条件改变所致。
