Di Martino G, di Matteo L, De Bellis G, Iannucci F, Molero U, Catena E
Boll Ist Sieroter Milan. 1979 Sep 30;58(4):344-55.
The Authors have tested serum levels of alpha-1-antitrypsin (A1AT), phosphohexose-isomerase (GPI) and carcinoembryonic antigen (CEA) in 133 patients affected with primary lung cancer, not treated with any drug, and in 183 patients affected with not neoplastic lung diseases or healthy, to control the utility of these markers in the early diagnosis of lung cancer. In many patients all the tests have been made at the same time. The three tumoral markers have been also examined in connection with the histological kinds of lung cancer. Results show that is suitable to test GIP and A1AT at the same time because they are percentually more pathological; serum levels of CEA, that are not very elevated in the pathological cases, seem in correlation with the histological kind of cancer.
作者检测了133例未经任何药物治疗的原发性肺癌患者以及183例患有非肿瘤性肺部疾病或健康者的血清α-1-抗胰蛋白酶（A1AT）、磷酸己糖异构酶（GPI）和癌胚抗原（CEA）水平，以评估这些标志物在肺癌早期诊断中的效用。在许多患者中，所有检测均同时进行。还结合肺癌的组织学类型对这三种肿瘤标志物进行了检查。结果表明，同时检测GIP和A1AT是合适的，因为它们的异常率更高；病理情况下CEA血清水平升高不明显，似乎与癌症的组织学类型相关。
