Di Martino G, Iannucci F, Bizzarro A, Iacono G
Boll Ist Sieroter Milan. 1982;61(5):411-22.
The Authors have tested serum levels of CEA, ferritin, Alpha-1-antitrypsin, parathyroid hormone (PTH) and calcitonin (CT) in 286 patients affected by lung, gastrointestinal, breast and other kinds of cancer and by non neoplastic diseases. 50 healthy subjects were tested as matched controls too. None of the tested patients was subjected to blood transfusion, therapy with iron, radio- or chemotherapy before the blood drawing. Cea, ferritin, PTH and CT were tested by radioimmunoassay; AAT by laser nephelometry. All the healthy subjects showed serum levels of the markers in the normal ranges. Also the percent of cases with contemporaneous pathological markers was examined. The obtained data have been statistically controlled with "chi square" test. The results show that CEA, ferritin, AAT and CT are higher in the tumor groups than in the others. On the contrary PTH seems to be not useful as tumor marker. The Authors conclude affirming that it is not possible to use any of the tested substances as a specific tumor marker but it is useful to test at the same time these markers in the patients suspected to be affected by cancer for an early diagnosis and therapy, as there are few false positive and false negative cases.
作者检测了286例患有肺癌、胃肠道癌、乳腺癌及其他类型癌症以及非肿瘤性疾病患者的癌胚抗原（CEA）、铁蛋白、α1抗胰蛋白酶、甲状旁腺激素（PTH）和降钙素（CT）的血清水平。还检测了50名健康受试者作为匹配对照。在采血前，所有受试患者均未接受输血、铁剂治疗、放疗或化疗。CEA、铁蛋白、PTH和CT采用放射免疫法检测；α1抗胰蛋白酶采用激光散射比浊法检测。所有健康受试者的标志物血清水平均在正常范围内。同时还检查了同时出现病理标志物的病例百分比。所得数据用“卡方”检验进行统计学对照。结果显示，肿瘤组的CEA、铁蛋白、α1抗胰蛋白酶和CT高于其他组。相反，PTH似乎作为肿瘤标志物并无用处。作者总结称，不可能将任何一种受试物质用作特异性肿瘤标志物，但对于疑似患癌患者同时检测这些标志物以进行早期诊断和治疗是有用的，因为假阳性和假阴性病例很少。
