Lowe K C, Bollands A D
Department of Zoology, University of Nottingham, U.K.
Biomater Artif Cells Artif Organs. 1988;16(1-3):495-504. doi: 10.3109/10731198809132604.
The effects of a single, low dose (10 ml/kg) injection of the perfluorochemical (PFC) emulsion, Fluosol-DA 20%, on lymphoid tissues and antibody production against sheep red blood cells (SRBC) have been studied relative to the timing of immunization in rats and mice. Intravenous (i.v.) or intraperitoneal (i.p.) injection of emulsion in both species produced alterations in lymphoid tissue weights and the magnitude of these responses was highly tissue- and species-specific. Injection of Fluosol-DA tended to potentiate the humoral immune response to SRBC but this depended on timing and route of emulsion administration relative to immunization. We conclude that lymphoid tissue responses to emulsified PFCs are highly variable and depend upon a number of factors including: emulsion composition and dose; route and timing of administration relative to immunological "challenge"; tissue and species examined.
已针对大鼠和小鼠免疫接种的时间，研究了单次低剂量（10毫升/千克）注射全氟化合物（PFC）乳液Fluosol - DA 20%对淋巴组织以及针对绵羊红细胞（SRBC）的抗体产生的影响。在这两个物种中，静脉内（i.v.）或腹腔内（i.p.）注射乳液均会引起淋巴组织重量的改变，且这些反应的程度具有高度的组织和物种特异性。注射Fluosol - DA倾向于增强对SRBC的体液免疫反应，但这取决于乳液给药相对于免疫接种的时间和途径。我们得出结论，淋巴组织对乳化PFC的反应高度可变，并且取决于许多因素，包括：乳液组成和剂量；相对于免疫“刺激”的给药途径和时间；所检查的组织和物种。
