Bollands A D, Lowe K C, Sharma S K, Davis S S
Department of Zoology, University of Nottingham, University Park, UK.
J Pharm Pharmacol. 1987 Dec;39(12):1021-4. doi: 10.1111/j.2042-7158.1987.tb03152.x.
The effects of a novel perfluorochemical emulsion on rat lymphoid tissues and antibody production against sheep red blood cells (SRBC) have been studied. The responses were compared with those following injection of identical doses of the proprietary emulsion, Fluosol-DA 20% (F-DA). Liver weight was increased up to 15% at 8 days following intravenous (i.v.) or intraperitoneal (i.p.) injection of the novel emulsion but was unaffected by F-DA injection. Spleen weight also increased by a maximum of 20% in response to i.p. injection of the novel emulsion but this was less than increases of up to 44% which occurred in F-DA-injected rats. Thymus weight decreased (P less than 0.05) following i.p. injection of the novel emulsion whereas mesenteric lymph node (MLN) weight remained unchanged. However, MLN weight was increased in response to i.v. injected F-DA, while thymus weight showed a small increase following i.p. F-DA injection. Mean plasma antibody titres to SRBC were significantly (P less than 0.01) increased at 7 days after immunization in rats pretreated with i.p. injections of either the novel emulsion or F-DA; titres in animals pretreated with i.v. injections of either emulsion were similar to control.
研究了一种新型全氟化合物乳剂对大鼠淋巴组织以及针对绵羊红细胞（SRBC）抗体产生的影响。将这些反应与注射相同剂量的专利乳剂氟碳乳剂-DA 20%（F-DA）后的反应进行了比较。静脉内（i.v.）或腹腔内（i.p.）注射新型乳剂后8天，肝脏重量增加了15%，但F-DA注射对其无影响。腹腔内注射新型乳剂后，脾脏重量也最多增加了20%，但这低于注射F-DA的大鼠中高达44%的增加幅度。腹腔内注射新型乳剂后胸腺重量下降（P<0.05），而肠系膜淋巴结（MLN）重量保持不变。然而，静脉注射F-DA后MLN重量增加，腹腔注射F-DA后胸腺重量有小幅增加。腹腔注射新型乳剂或F-DA预处理的大鼠在免疫后7天，针对SRBC的平均血浆抗体滴度显著（P<0.01）升高；静脉注射任何一种乳剂预处理的动物的滴度与对照组相似。
