Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av. de las Ciencias S/N, Juriquilla, Querétaro, CP, 76230, Mexico.
Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Obes Res Clin Pract. 2019 Nov-Dec;13(6):533-540. doi: 10.1016/j.orcp.2019.10.012. Epub 2019 Nov 30.
Overweight/obesity, dyslipidemias, hypertension and hyperglycemia are strongly related to non-communicable diseases (NCD) in which genetic and environmental factors interact with each other. The Mexican population exhibit a genetic disposition to metabolic syndrome, type 2 diabetes, as well as many forms of dyslipidemia. This study aimed to determine the association between biochemical, genetic and environmental factors in the development of metabolic syndrome (MS), obesity and insulin resistance (IR) in Mexican young adults. Young women and men (n=6750 between 19.3±2.3 years old) participated in a health promotion program from the Autonomous University of Querétaro, México (SU-Salud program). A sub-sample of 665 participants was taken for the determination of single nucleotide polymorphisms (SNP) rs964184 (APOAV), rs9282541 (ABCA1) and rs1260326 (GCKR), using QuantStudio 12K Flex Real-Time PCR System. For the multivariate analysis, a multiple logistic regression was performed. A prevalence of 22% of overweight and 7% of obesity was determined. The main metabolic risk factors were low levels of HDL-C (30%), IR (19%), and a high level of triglycerides (15%). The main factors associated with IR were body fat percentage and triglycerides; SNP for the ABCA1 gene was related to MS, obesity and low HDL-C; SNP for GCKR gene was related to high fasting glycemia, while APOAV SNP was related with MS, hypertriglyceridemia and low HDL-C. Our findings show that the Mexican genetic predisposition to NCD affects young adults, who can suffer MS, obesity and IR. Public health strategies must focus on prevention actions from an early age.
超重/肥胖、血脂异常、高血压和高血糖与非传染性疾病（NCD）密切相关，其中遗传和环境因素相互作用。墨西哥人口具有代谢综合征、2 型糖尿病和多种形式血脂异常的遗传易感性。本研究旨在确定生化、遗传和环境因素在墨西哥年轻成年人代谢综合征（MS）、肥胖和胰岛素抵抗（IR）发展中的相关性。来自墨西哥自治大学（SU-Salud 计划）的年轻女性和男性（年龄在 19.3±2.3 岁之间，n=6750 人）参加了一项健康促进计划。从 665 名参与者中抽取了一部分用于确定单核苷酸多态性（SNP）rs964184（APOAV）、rs9282541（ABCA1）和 rs1260326（GCKR），使用 QuantStudio 12K Flex Real-Time PCR 系统。对于多变量分析，进行了多次逻辑回归。确定超重的患病率为 22%，肥胖的患病率为 7%。主要代谢风险因素是 HDL-C 水平低（30%）、IR（19%）和甘油三酯水平高（15%）。与 IR 相关的主要因素是体脂肪百分比和甘油三酯；ABCA1 基因的 SNP 与 MS、肥胖和低 HDL-C 相关；GCKR 基因的 SNP 与高空腹血糖相关，而 APOAV SNP 与 MS、高甘油三酯血症和低 HDL-C 相关。我们的研究结果表明，墨西哥对 NCD 的遗传易感性影响了年轻成年人，他们可能患有 MS、肥胖和 IR。公共卫生策略必须从早期开始注重预防措施。
