Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Adv Exp Med Biol. 2020;1237:29-36. doi: 10.1007/5584_2019_421.
The traditional view of the vascular biology is changed by the discovery of vascular progenitor cells in bone marrow or peripheral blood Further complexity is due to the findings that the vessel walls harbor progenitor and stem cells, called vascular wall-resident vascular stem cells (VW-VSCs), able to differentiate to mature vascular wall cells. These immature stem/progenitor cell populations and multipotent mesenchymal lineage participate in postnatal neovascularization and vascular wall remodeling. Further studies are necessary to deepen the knowledge on characterization and biology of VW-VSCs, in particular of endothelial progenitor cells (EPCs) in order to improve their use in clinical settings for regenerative approaches.
传统的血管生物学观点因在骨髓或外周血中发现血管祖细胞而发生改变。进一步的复杂性是由于发现血管壁中存在祖细胞和干细胞，称为血管壁驻留血管干细胞（VW-VSCs），能够分化为成熟的血管壁细胞。这些未成熟的干细胞/祖细胞群体和多能间充质谱系参与出生后新生血管形成和血管壁重塑。为了改善它们在再生方法的临床应用中的使用，有必要进一步研究 VW-VSCs，特别是内皮祖细胞（EPCs）的特性和生物学。
