Service d'Hématologie et Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Paris, France.
Eurocord, APHP, University Paris Diderot, Hôpital Saint Louis, Paris, France.
Curr Med Chem. 2018;25(35):4535-4544. doi: 10.2174/0929867324666171012110244.
Circulating endothelial cells (CECs), originated form endothelial progenitors (EPCs) are mature cells not associated with vessel walls and detached from the endothelium. Normally, they are present in insignificant amounts in the peripheral blood of healthy individuals. On the other hand, elevated CECs and EPCs levels have been reported in the peripheral blood of patients with different types of cancers and other diseases.
This review aims to provide an overview on the characterization of CECs and EPCs, to describe isolation methods and to identify the potential role of these cells in hematological diseases and hematopoietic stem cell transplantation.
We performed a detailed search of peer-reviewed literature using keywords related to CECs, EPCs, allogeneic hematopoietic stem cell transplantation, and hematological diseases (hemoglobinopathies, hodgkin and non-hodgkin lymphoma, acute leukemia, myeloproliferative syndromes, chronic lymphocytic leukemia).
CECs and EPCs are potential biomarkers for several clinical conditions involving endothelial turnover and remodeling, such as in hematological diseases. These cells may be involved in disease progression and in the neoplastic process. Moreover, CECs and EPCs are probably involved in endothelial damage which is a marker of several complications following allogeneic hematopoietic stem cell transplantation.
This review provides information about the role of CECs and EPCs in hematological malignancies and shows their implication in predicting disease activity as well as improving HSCT outcomes.
循环内皮细胞（CECs）起源于内皮祖细胞（EPCs），是成熟的细胞，不与血管壁相关，并且从内皮细胞上脱离。正常情况下，它们在健康个体的外周血中存在的数量微不足道。另一方面，在患有不同类型癌症和其他疾病的患者的外周血中已经报道了升高的 CECs 和 EPCs 水平。
本综述旨在概述 CECs 和 EPCs 的特征，描述其分离方法，并确定这些细胞在血液系统疾病和造血干细胞移植中的潜在作用。
我们使用与 CECs、EPCs、异基因造血干细胞移植和血液系统疾病（血红蛋白病、霍奇金和非霍奇金淋巴瘤、急性白血病、骨髓增生性综合征、慢性淋巴细胞白血病）相关的关键词，对同行评审文献进行了详细的搜索。
CECs 和 EPCs 是涉及内皮细胞更新和重塑的几种临床情况的潜在生物标志物，例如在血液系统疾病中。这些细胞可能参与疾病进展和肿瘤形成过程。此外，CECs 和 EPCs 可能参与了异基因造血干细胞移植后几种并发症的内皮损伤，这是内皮损伤的一个标志物。
本综述提供了 CECs 和 EPCs 在血液恶性肿瘤中的作用信息，并显示了它们在预测疾病活动和改善 HSCT 结果方面的意义。
