过氧化物酶体增殖物激活受体α（PPARα）是阿司匹林发挥神经保护作用的新型受体。
PPARα serves as a new receptor of aspirin for neuroprotection.
机构信息
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
出版信息
J Neurosci Res. 2020 Apr;98(4):626-631. doi: 10.1002/jnr.24561. Epub 2019 Dec 3.
Abstract
Acetyl salicylic acid, commonly known as aspirin, has been being widely used as an anti-inflammatory drug for almost 100 years. However, there was no receptor known for this popular drug. Recently, we have established that peroxisome proliferator-activated receptor alpha (PPARα) acts as a novel receptor of aspirin. Activation of PPARα by aspirin stimulated a series of downstream signaling pathways that could potentially ameliorate different Alzheimer's disease (AD)-related pathologies. In this mini-review, we have discussed how aspirin-PPARα interaction plays a pivotal role in the amelioration of AD pathology via the stimulation of neurotrophic factors, upregulation of plasticity-associated genes, and removal of plaque burden in hippocampal neurons.
摘要
乙酰水杨酸，俗称阿司匹林，作为一种抗炎药物，已经广泛应用近 100 年。然而，这种广受欢迎的药物却没有已知的受体。最近，我们已经确定过氧化物酶体增殖物激活受体α（PPARα）是阿司匹林的一种新型受体。阿司匹林激活 PPARα 会刺激一系列下游信号通路，这些通路可能有助于改善不同的阿尔茨海默病（AD）相关病理。在这篇简评中，我们讨论了阿司匹林-PPARα 相互作用如何通过刺激神经营养因子、上调与可塑性相关的基因以及清除海马神经元中的斑块负担，在改善 AD 病理方面发挥关键作用。
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