Hollóczki Oldamur
Mulliken Center for Theoretical Chemistry, University of Bonn, Beringstrasse 4+6, 53115, Bonn, Germany.
Chemistry. 2020 Apr 16;26(22):4885-4894. doi: 10.1002/chem.201903021. Epub 2020 Feb 11.
The term "N-Heterocyclic carbene organocatalysis" is often invoked in organic synthesis for reactions that are catalyzed by different azolium salts in the presence of bases. Although the mechanism of these reactions is considered today evident, a closer look into the details that have been collected throughout the last century reveals that there are many open questions and even contradictions in the field. Emerging new theoretical and experimental results offer solutions to these problems, because they show that through considering alternative reaction mechanisms a more consistent picture on the catalytic process can be obtained. These novel perspectives will be able to extend the scope of the reactions that we call today N-heterocyclic carbene organocatalysis.
“N-杂环卡宾有机催化”一词常用于有机合成中，指在碱存在下由不同唑盐催化的反应。尽管如今这些反应的机理被认为是明确的，但仔细审视上个世纪收集到的细节会发现，该领域仍存在许多未解决的问题甚至矛盾之处。新出现的理论和实验结果为这些问题提供了解决方案，因为它们表明，通过考虑替代反应机理，可以获得关于催化过程更一致的图景。这些新颖的观点将能够扩展我们如今所称的N-杂环卡宾有机催化反应的范围。
