Grisel Judith E, Crabbe John C
Judith E. Grisel, Ph.D., is a postdoctoral fellow and John C. Crabbe, Ph.D., is both a research career scientist at the Department of Veterans Affairs Medical Center and a professor at the School of Medicine, Oregon Health Sciences University, Portland, Oregon.
Alcohol Health Res World. 1995;19(3):220-227.
Researchers interested in the physical locations of genes that influence a person's alcohol-related behaviors can use a method known as quantitative trait loci (QTL) mapping to identify the approximate locations of genes in the genome. QTL mapping can use recombinant inbred mouse strains, which are sets of inbred strains derived from cross-breeding the offspring of two genetically distinct parent strains. The inbred strains exhibit different patterns of the parent strains' genes. QTL mapping involves comparing alcohol-related behaviors in these strains and identifying patterns of known genetic markers shared by strains with the same behaviors. The markers allow the identification of probable locations of genes that influence alcohol-related behaviors. These locations can then be verified using other tests, and specific genes can be sought there.
对影响人类酒精相关行为的基因的物理位置感兴趣的研究人员，可以使用一种称为数量性状基因座（QTL）定位的方法来确定基因组中基因的大致位置。QTL定位可以使用重组近交小鼠品系，这些品系是通过将两个基因不同的亲本品系的后代进行杂交培育而成的近交品系集合。这些近交品系表现出亲本品系基因的不同模式。QTL定位包括比较这些品系中与酒精相关的行为，并识别具有相同行为的品系所共有的已知遗传标记模式。这些标记有助于识别影响酒精相关行为的基因的可能位置。然后可以使用其他测试来验证这些位置，并在那里寻找特定的基因。
