Mojtahedi Sayed Yousef, Abbasi Arash, Izadi Anahita, Alavije Fahimeh Shahsavari, Fahimi Daryoush
Department of Pediatric Nephrology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatrics, Division of Nephrology, Children's Hospital Medical Center, Tehran, Iran, Tehran University of Medical Sciences. Tehran, Iran.
Maedica (Bucur). 2019 Sep;14(3):270-273. doi: 10.26574/maedica.2019.14.3.270.
Children with urolithiasis have a wide range of metabolic disorders which should be carefully considered. The response to medical treatment could predict recurrence and need for surgical interventions. The goal of this retrospective study is to determine the prevalence of metabolic disorders in Iranian children and assess patients' response to treatment based on the etiology of their urolithiasis. Medical record of 100 children with urolithiasis who were referred to Bahrami hospital (affiliated hospital of Tehran University of Medical Sciences) between 2007 and 2017. Data regarding age, sex, family history, symptoms, size of the stones, type of treatments, response to treatment, and recurrence were recorded for all cases Subjects had a mean age of 36 ±36 months and 62 (62%) of them were females. Twenty-two percent had a family history of urolithiasis. The mean age was 37.2±35 months in the complete response group, 38±44.4 months in the partial group, and 30±33.1 months in the no response group (p=0.7). There was no significant difference regarding sex and age with treatment response (p=0.8). In the complete response group, nearly 72% of cases had stones with sizes less than 3 mm. Three cases had surgical interventions and 18 had recurrence. Hypercalciuria followed by hyperoxaluria were the most common metabolic disorders in Iranian children with urolithiasis. Stone size plays an important role in the response to treatment.
患有尿路结石的儿童存在多种代谢紊乱，对此应予以仔细考虑。药物治疗的反应可预测复发情况及手术干预的必要性。这项回顾性研究的目的是确定伊朗儿童代谢紊乱的患病率，并根据尿路结石的病因评估患者的治疗反应。回顾了2007年至2017年间转诊至巴赫拉米医院（德黑兰医科大学附属医院）的100例尿路结石患儿的病历。记录了所有病例的年龄、性别、家族史、症状、结石大小、治疗类型、治疗反应和复发情况。受试者的平均年龄为36±36个月，其中62例（62%）为女性。22%的患儿有尿路结石家族史。完全缓解组的平均年龄为37.2±35个月，部分缓解组为38±44.4个月，无反应组为30±33.1个月（p=0.7）。性别和年龄与治疗反应之间无显著差异（p=0.8）。在完全缓解组中，近72%的病例结石大小小于3毫米。3例接受了手术干预，18例复发。高钙尿症继之以高草酸尿症是伊朗尿路结石患儿最常见的代谢紊乱。结石大小在治疗反应中起重要作用。
