Bengtsson Alexander, Hill David, Li Meng, Di Mengqiao, Cinthio Magnus, Erlöv Tobias, Andersson-Engels Stefan, Reistad Nina, Walther Andreas, Rippe Lars, Kröll Stefan
Department of Physics, Lund University, 221 00 Lund, Sweden.
SpectraCure AB, 222 29 Lund, Sweden.
Biomed Opt Express. 2019 Oct 7;10(11):5565-5584. doi: 10.1364/BOE.10.005565. eCollection 2019 Nov 1.
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.
超声光学层析成像（UOT）是一种基于声光效应的成像技术，它能够在浑浊介质内部以超声分辨率进行光学成像，因此在生物医学应用中具有吸引力，例如用于评估组织的血液氧合情况。在本文中，我们展示了使用慢光滤波器信号检测对UOT信号强度进行近背景自由测量的方法。我们仔细分析了实验装置的每个部分，并将测量的信号强度与基于扩散理论的计算结果进行匹配。实验与理论之间的这种一致性使我们能够更有信心地断言先前理论研究[《生物医学光学快报》8, 4523 (2017)]所预测的UOT对真实人体组织进行厘米级深度组织成像的潜力，并表明对优化后的UOT系统进行未来的理论分析有望是可靠的。
