持续性寨卡病毒感染与早期胎儿死亡相关：一例报告
Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report.
作者信息
Pérez-Padilla Janice, Paz-Bailey Gabriela, Meaney-Delman Dana, Doyle Kate, Gary Joy, Rodriguez Dania M, Bhatnagar Julu, Pérez-Rodriguez Nicole M, Montalvo Sara, Alvarado Luisa, Sharp Tyler M
机构信息
Centers for Disease Control and Prevention (CDC), Dengue Branch, San Juan, Puerto Rico.
CDC, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, USA.
出版信息
Open J Obstet Gynecol. 2019 May;9(5):698-706. doi: 10.4236/ojog.2019.95069.
BACKGROUND
Infection with Zika virus (ZIKV) during pregnancy is known to cause birth defects and could also be linked to pregnancy loss.
CASE
A pregnant woman in Puerto Rico contracted ZIKV at 16 weeks gestation. ZIKV RNA persisted in serum from her initial test at 16 weeks through 24 weeks gestation, when fetal demise occurred, and was detected in placental tissue.
CONCLUSION
Prolonged detection of ZIKV RNA in maternal serum was associated with ZIKV RNA detection in the placenta of a patient who experienced fetal demise. While detection of placenta ZIKV RNA does not establish that ZIKV conclusively caused the demise, these findings support emerging evidence that the placenta may serve as a reservoir for ZIKV, which may be associated with prolonged detection of ZIKV RNA in serum.
背景
已知孕期感染寨卡病毒（ZIKV）会导致出生缺陷，也可能与流产有关。
病例
一名波多黎各孕妇在妊娠16周时感染了寨卡病毒。寨卡病毒RNA在她妊娠16周初次检测时的血清中持续存在，直至妊娠24周胎儿死亡时仍可检测到，且在胎盘组织中也被检测到。
结论
在一名经历胎儿死亡的患者中，母体血清中寨卡病毒RNA的长期检测与胎盘中寨卡病毒RNA的检测相关。虽然胎盘寨卡病毒RNA的检测并不能确定寨卡病毒是导致胎儿死亡的确切原因，但这些发现支持了新出现的证据，即胎盘可能是寨卡病毒的储存库，这可能与血清中寨卡病毒RNA的长期检测有关。
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