Hu Xiaopeng, Li Xinyue, Tian Geng G, Zhang Huijuan, Cheng Weiwei, Wu Ji
Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China.
International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Data Brief. 2019 Nov 12;27:104795. doi: 10.1016/j.dib.2019.104795. eCollection 2019 Dec.
This data descriptor is an extended version of the methodologies which have been described in a related paper [1]; its purpose is to disseminate the raw data and analyzed data produced in this experiment. For more insight please see the research article, "competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia" (Xiaopeng Hu and Junping Ao, 2018) [1]. Using microarray analysis, we investigated competing endogenous RNA (ceRNA) expression profiles in placentas of women with severe pre-eclampsia (SPE) and normal pregnancies. Competing endogenous RNA (ceRNA) refer to RNA transcripts, such as messenger RNA (mRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) that can regulate each other by competing for the same pool of miRNAs. CircRNAs, lncRNAs, and mRNAs differentially expressed between human normal and SPE placentas were obtained in the study. Metadata files were submitted to the Gene Expression Omnibus repository (GEO), with GEO accession number GSE102897. These data are potential useful for further study on the pathogenesis of PE and early prediction of PE onset.
本数据描述是一篇相关论文[1]中所描述方法的扩展版本；其目的是传播本实验产生的原始数据和分析数据。如需更深入了解，请参阅研究文章“子痫前期中竞争性内源性RNA表达谱鉴定出hsa_circ_0036877作为早发型子痫前期潜在的新型血液生物标志物”（胡小鹏和敖俊平，2018年）[1]。我们使用微阵列分析研究了重度子痫前期（SPE）孕妇和正常妊娠孕妇胎盘组织中的竞争性内源性RNA（ceRNA）表达谱。竞争性内源性RNA（ceRNA）是指信使核糖核酸（mRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）等RNA转录本，它们可通过竞争相同的微小RNA（miRNA）池相互调节。本研究获得了人正常胎盘组织与SPE胎盘组织之间差异表达的环状RNA、长链非编码RNA和信使核糖核酸。元数据文件已提交至基因表达综合数据库（GEO），登录号为GSE102897。这些数据对于进一步研究子痫前期的发病机制和子痫前期发病的早期预测具有潜在的参考价值。
