Department of Psychology, University of Turin, Italy.
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway.
Brain Res. 2020 Feb 1;1728:146591. doi: 10.1016/j.brainres.2019.146591. Epub 2019 Dec 7.
The hippocampal complex, strongly implicated in Alzheimer's disease (AD), is a region with functionally and structurally distinct subfields. Hippocampal subfield volumes may represent a more sensitive indicators of AD development than total hippocampal volume. We aimed to identify which subfield is the most predictive measure for an AD diagnosis and which is the most specific indicator of the conversion from mild cognitive impairment (MCI) to AD. We analyzed longitudinal structural neuroimaging data of 1350 individuals, 350 healthy controls (HC), 650 MCI and 350 AD, using FreeSurfer v6.0. The linear regression models corrected for total hippocampal volume revealed that subicular fields are the most predictive measures of AD diagnosis. Hippocampal fissure volume was significantly associated with conversion from MCI to AD. Our findings suggest that subicular hippocampal fields are most predictive of AD diagnosis, which has clinical implications for early detection. Specifically, subicular and hippocampal fissure volume measures may be used to select MCI participants who are most likely to convert in AD in clinical trials.
海马复合体强烈提示与阿尔茨海默病（AD）有关，它是一个具有功能和结构上明显不同的子区域的区域。海马亚区体积可能比总海马体积更能敏感地反映 AD 的发展。我们旨在确定哪个子区域是 AD 诊断的最具预测性的测量指标，以及哪个是从轻度认知障碍（MCI）向 AD 转化的最特异性指标。我们使用 FreeSurfer v6.0 分析了 1350 名个体的纵向结构神经影像学数据，其中包括 350 名健康对照者（HC）、650 名 MCI 和 350 名 AD。经过总海马体积校正的线性回归模型显示，内嗅皮质场是 AD 诊断的最具预测性的测量指标。海马裂体积与从 MCI 向 AD 的转化显著相关。我们的研究结果表明，内嗅皮质海马区是 AD 诊断的最具预测性的指标，这对早期发现具有临床意义。具体来说，内嗅皮质和海马裂体积的测量值可用于在临床试验中选择最有可能转化为 AD 的 MCI 参与者。
