The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China.
Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Brain Imaging Behav. 2023 Dec;17(6):778-793. doi: 10.1007/s11682-023-00804-3. Epub 2023 Sep 28.
The hippocampus is a complex structure that consists of several subfields with distinct and specialized functions. Although numerous studies have been performed to explore hippocampal atrophy at the sub-regional level in mild cognitive impairment (MCI) and Alzheimer's disease (AD), the results have been inconsistent especially for whether and which subfields can be served as the most potential biomarkers in MCI and AD. Herein, we used a meta-analytic approach to synthesize the extant literatures on hippocampal subfields in MCI and AD through PubMed, Web of Science, and Embase (PROSPERO CRD42021257586). As a result, a total of twenty studies using Freesurfer 5 and Freesurfer 6 were included in this investigation. These studies revealed that at the sub-regional level, hippocampal subfield volume reductions in MCI and AD were not restricted to specific subfields, and subiculum and presubiculum had the largest z-scores across most comparisons. However, none of the subfield performed much better in discriminating MCI and HC, AD and MCI, AD and HC as compared to whole hippocampus volume. These results suggested that we should explore the changes in the hippocampal subfields in subtypes of MCI or even at an earlier stage, that is subjective cognitive impairment.
海马体是一个复杂的结构，由几个具有不同和专门功能的子区域组成。尽管已经有许多研究致力于探索轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 中海马体萎缩的亚区域水平，但结果并不一致，特别是在 MCI 和 AD 中哪些子区域可以作为最有潜力的生物标志物。在此，我们通过 PubMed、Web of Science 和 Embase (PROSPERO CRD42021257586) 采用荟萃分析的方法综合了 MCI 和 AD 中海马体亚区域的现有文献。结果，共纳入了 20 项使用 Freesurfer 5 和 Freesurfer 6 的研究。这些研究表明，在亚区域水平上，MCI 和 AD 中海马体亚区域体积的减少并不仅限于特定的亚区域，而在大多数比较中，海马旁回和前海马旁回的 z 值得分最大。然而，与整个海马体体积相比，没有任何一个亚区域在区分 MCI 和 HC、AD 和 MCI、AD 和 HC 方面表现得更好。这些结果表明，我们应该探索 MCI 亚型甚至更早阶段（即主观认知障碍）中海马体亚区域的变化。
