鸡泪液中免疫球蛋白A产生对哈德氏腺的依赖性
Harderian gland dependency of immunoglobulin A production in the lacrimal fluid of chicken.
作者信息
Baba T, Masumoto K, Nishida S, Kajikawa T, Mitsui M
机构信息
Department of Veterinary Microbiology, College of Agriculture, University of Osaka Prefecture, Japan.
出版信息
Immunology. 1988 Sep;65(1):67-71.
Involvement of the Harderian gland (HG) in the production of lacrimal immunoglobulin (especially IgA) was investigated. The lacrimal concentration of each immunoglobulin class was not affected by surgical bursectomy but was reduced by cyclophosphamide (CY) and testosterone (TP) treatments. Surgical removal of the Harderian gland caused a remarkable reduction of both the lacrimal concentration of each immunoglobulin class and the specific antibody titre, and and IgA was almost undetectable. The lacrimal concentration of each immunoglobulin class, as well as the specific antibody titre, was not affected by surgical removal of the Lacrimal gland (LG). The route of antigen administration produced no difference in the class of lacrimal immunoglobulin produced. The results indicate that the production of immunoglobulin in chicken tears may be dependent on the HG and that lacrimal immunoglobulin may be synthesized and secreted locally in the HG. Lymphocytes of the HG are of bursa of Fabricius origin and are seeded into the HG prior to hatching and its lymphocytes do not appear to be involved in systemic immunity.
研究了哈德氏腺（HG）在泪液免疫球蛋白（尤其是IgA）产生中的作用。每种免疫球蛋白类别的泪液浓度不受手术切除法氏囊的影响，但环磷酰胺（CY）和睾酮（TP）处理可使其降低。手术切除哈德氏腺导致每种免疫球蛋白类别的泪液浓度和特异性抗体滴度显著降低，且IgA几乎检测不到。每种免疫球蛋白类别的泪液浓度以及特异性抗体滴度不受手术切除泪腺（LG）的影响。抗原给药途径对产生的泪液免疫球蛋白类别没有差异。结果表明，鸡泪液中免疫球蛋白的产生可能依赖于HG，且泪液免疫球蛋白可能在HG中局部合成和分泌。HG的淋巴细胞起源于法氏囊，在孵化前植入HG，其淋巴细胞似乎不参与全身免疫。
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