Hasan S A, Brain P F, Castano D
Biomedical and Physiological Research Group, University College of Swansea, United Kingdom.
Horm Behav. 1988 Jun;22(2):178-85. doi: 10.1016/0018-506x(88)90064-5.
The anti-estrogen tamoxifen (Tam), which has been shown to dramatically suppress offensive behavior in male rats without markedly influencing other aspects of the social encounter, was tested for its effectiveness in mice. TO strain albino mice were given control injections or 50 or 100 micrograms of Tam for 4 or 8 days. Subsequently, mice were tested in pairs (for a particular dose and treatment duration) in which both animals received Tam, one animal received Tam and one saline, or both animals received saline control injections. Ten-minute videotaped encounters were analyzed in terms of total times allocated to nonsocial investigation, social investigation, offense, defense, sexual activity/intense social investigation, and immobility. The lower dose given for the shorter duration produced less social investigation and more nonsocial investigation when Tam-treated subjects were paired together (cf. the Tam vs saline pairing). At all the other doses and durations, Tam reduced offense. Defense also changed in those pairings, but that activity seemed related to the amount of attack received. Tamoxifen had little influence on the weights of accessory sex glands. The data confirm that Tam is a potent suppressor of "androgen-dependent" aggression in male laboratory mice and provide further support for the aromatization hypothesis.
抗雌激素他莫昔芬（Tam）已被证明能显著抑制雄性大鼠的攻击行为，而对社交互动的其他方面影响不大，本研究对其在小鼠中的有效性进行了测试。将TO品系白化小鼠分为三组，分别接受对照注射，或连续4天或8天注射50微克或100微克的他莫昔芬。随后，将小鼠配对进行测试（针对特定剂量和治疗持续时间），其中两只动物都接受他莫昔芬，一只动物接受他莫昔芬而另一只接受生理盐水，或两只动物都接受生理盐水对照注射。对10分钟的录像互动进行分析，记录分配给非社交探究、社交探究、攻击、防御、性活动/强烈社交探究和静止不动的总时间。当接受他莫昔芬治疗的小鼠配对在一起时（与他莫昔芬与生理盐水配对相比），较短治疗持续时间的较低剂量会导致社交探究减少，非社交探究增加。在所有其他剂量和持续时间下，他莫昔芬都会减少攻击行为。在这些配对中防御行为也发生了变化，但这种行为似乎与受到的攻击量有关。他莫昔芬对附属性腺的重量影响很小。数据证实他莫昔芬是雄性实验小鼠“雄激素依赖性”攻击行为的有效抑制剂，并为芳香化假说提供了进一步支持。
