使用局部光动力疗法的场癌化治疗：两种氨基乙酰丙酸衍生物的比较。
Field cancerization treatment using topical photodynamic therapy: A comparison between two aminolevulinate derivatives.
作者信息
de Oliveira Elisangela Ramos, Inada Natalia M, Blanco Kate Cristina, Bagnato Vanderlei S, Salvio Ana Gabriela
机构信息
Hospital Amaral Carvalho, Jaú, SP, Brazil.
São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.
出版信息
Photodiagnosis Photodyn Ther. 2020 Jun;30:101603. doi: 10.1016/j.pdpdt.2019.101603. Epub 2019 Dec 9.
The objective of this study was to evaluate and compare the clinical response to PDT (Photodynamic Therapy) in field cancerization using two aminolevulinate derivatives. Forty patients with multiple actinic keratosis (AK) on forearms and hands scattered received two sessions of ALA and MAL-PDT at 630 nm (36 J/cm). The AK clearance rate was 72 % for both drugs with a significant decrease in AK observed clinically (p < 00,001). Clinical improvement in field cancerization using two aminolevulinate derivatives in PDT is proven with no significant difference in the efficacy of drugs.
本研究的目的是评估和比较两种氨基乙酰丙酸衍生物在光动力疗法（PDT）治疗场癌化中的临床反应。40例在前臂和手部散在分布有多个光化性角化病（AK）的患者接受了两次630nm（36J/cm）的ALA和MAL-PDT治疗。两种药物的AK清除率均为72%，临床观察到AK显著减少（p<0.001）。已证实使用两种氨基乙酰丙酸衍生物进行PDT治疗场癌化有临床改善，且药物疗效无显著差异。
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