Wijnands W J, Vree T B, Baars A M, Hafkenscheid J C, Kohler B E, van Herwaarden C L
Department of Pulmonary Diseases, Foundation Deventer Hospital, The Netherlands.
J Antimicrob Chemother. 1988 Sep;22 Suppl C:85-9. doi: 10.1093/jac/22.supplement_c.85.
After a single oral 600 mg dose, ofloxacin concentrations were measured in lung tissue, whole blood and plasma in 11 patients undergoing thoracotomy for a bronchial malignancy. To correct for blood contamination in the tissue samples, the tissue haemoglobin content was measured using a method based on the binding of haemoglobin by haptoglobin. Ofloxacin concentrations in plasma and whole blood did not differ significantly. The calculated blood content in the tissue samples was 0.12 +/- 0.05 ml/g lung tissue. After correction for blood admixture, the mean lung tissue concentration 2 h after administration of ofloxacin was 17.7 +/- 9.2 micrograms/g. At the same time the mean plasma concentration was 8.7 +/- 4.2 mg/l (P less than 0.02). The high concentration of ofloxacin obtained in lung tissue does not result from the preparation technique. After a single 600 mg dose the tissue concentrations proved to exceed MIC values for most pathogens frequently involved in respiratory tract infections.
对11例因支气管恶性肿瘤接受开胸手术的患者口服600mg剂量的氧氟沙星后，测定其肺组织、全血和血浆中的氧氟沙星浓度。为校正组织样本中的血液污染，采用基于触珠蛋白与血红蛋白结合的方法测定组织血红蛋白含量。血浆和全血中的氧氟沙星浓度无显著差异。计算得出组织样本中的血液含量为0.12±0.05ml/g肺组织。校正血液混合后，氧氟沙星给药后2小时肺组织平均浓度为17.7±9.2μg/g。同时，平均血浆浓度为8.7±4.2mg/l（P<0.02）。肺组织中获得的高浓度氧氟沙星并非由制备技术导致。单次600mg剂量后，组织浓度被证明超过了大多数呼吸道感染常见病原体的最低抑菌浓度值。
