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Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.单次口服200毫克氧氟沙星后其在人肺组织中的渗透情况。 （你提供的原文中多了一个of，正确的应该是Penetration of ofloxacin... 这里按照修正后的翻译）
Antimicrob Agents Chemother. 1991 Feb;35(2):380-1. doi: 10.1128/AAC.35.2.380.
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The penetration of ofloxacin into lung tissue.氧氟沙星在肺组织中的渗透。 需注意，原文中“of ofloxacin”多了一个“of”，正确表述应为“The penetration of ofloxacin into lung tissue.”
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The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration.
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1
Diffusion of ofloxacin into human lung tissue.氧氟沙星在人肺组织中的扩散。 需要说明的是，原文中“Diffusion of ofloxacin into human lung tissue.”多了一个“of”，正确表述应该是“Diffusion of ofloxacin into human lung tissue” 。
Drugs. 1987;34 Suppl 1:37-8. doi: 10.2165/00003495-198700341-00009.
2
Comparative pharmacokinetics of new quinolones.新型喹诺酮类药物的比较药代动力学
Drugs. 1987;34 Suppl 1:21-5. doi: 10.2165/00003495-198700341-00006.
3
The penetration of ofloxacin into lung tissue.氧氟沙星在肺组织中的渗透。 需注意，原文中“of ofloxacin”多了一个“of”，正确表述应为“The penetration of ofloxacin into lung tissue.”
J Antimicrob Chemother. 1988 Sep;22 Suppl C:85-9. doi: 10.1093/jac/22.supplement_c.85.
4
Pharmacokinetics of enoxacin and its penetration into bronchial secretions and lung tissue.依诺沙星的药代动力学及其在支气管分泌物和肺组织中的渗透情况。
J Antimicrob Chemother. 1988 Feb;21 Suppl B:67-77. doi: 10.1093/jac/21.suppl_b.67.
5
The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.氟喹诺酮类药物：结构、作用机制与耐药性以及体外活性谱
Antimicrob Agents Chemother. 1985 Oct;28(4):581-6. doi: 10.1128/AAC.28.4.581.
6
Tissue penetration of the new quinolones in humans.新型喹诺酮类药物在人体中的组织穿透性。
Rev Infect Dis. 1989 Jul-Aug;11 Suppl 5:S1046-57. doi: 10.1093/clinids/11.supplement_5.s1046.

单次口服200毫克氧氟沙星后其在人肺组织中的渗透情况。 （你提供的原文中多了一个of，正确的应该是Penetration of ofloxacin... 这里按照修正后的翻译）

Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.

作者信息

Serour F, Dan M, Gorea A, Yellin A, Lieberman Y, Berger S A

机构信息

Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Antimicrob Agents Chemother. 1991 Feb;35(2):380-1. doi: 10.1128/AAC.35.2.380.

DOI:10.1128/AAC.35.2.380
PMID:2024972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245011/
Abstract

The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

摘要

对10例接受肺部手术的患者研究了氧氟沙星在肺组织中的渗透情况。口服200毫克后3至8小时（平均5小时）采集血液和肺组织样本。组织中的平均水平为2.17±0.5微克/克，而血清中的平均水平为0.85±0.23微克/毫升。肺组织/血清浓度平均比值为2.55±0.30。对于大多数肺部病原体，肺组织中可达到的氧氟沙星水平高于其最低抑菌浓度。