Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.
作者信息
Serour F, Dan M, Gorea A, Yellin A, Lieberman Y, Berger S A
机构信息
Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, Israel.
出版信息
Antimicrob Agents Chemother. 1991 Feb;35(2):380-1. doi: 10.1128/AAC.35.2.380.
Abstract
The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.
摘要
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