单次口服200毫克氧氟沙星后其在人肺组织中的渗透情况。 （你提供的原文中多了一个of，正确的应该是Penetration of ofloxacin... 这里按照修正后的翻译）
Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.
作者信息
Serour F, Dan M, Gorea A, Yellin A, Lieberman Y, Berger S A
机构信息
Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, Israel.
出版信息
Antimicrob Agents Chemother. 1991 Feb;35(2):380-1. doi: 10.1128/AAC.35.2.380.
Abstract
The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.
摘要
对10例接受肺部手术的患者研究了氧氟沙星在肺组织中的渗透情况。口服200毫克后3至8小时（平均5小时）采集血液和肺组织样本。组织中的平均水平为2.17±0.5微克/克，而血清中的平均水平为0.85±0.23微克/毫升。肺组织/血清浓度平均比值为2.55±0.30。对于大多数肺部病原体，肺组织中可达到的氧氟沙星水平高于其最低抑菌浓度。
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