Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Exp Physiol. 2020 Apr;105(4):565-570. doi: 10.1113/EP088096. Epub 2020 Jan 9.
What is the topic of this review? Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems. What advances does it highlight? Impairments to mitochondrial functions and morphology may be a primary mechanism underlying the pathophysiology of various complications in people with type 1 diabetes.
We recently made the observation that there are significant alterations to the ultrastructure and functions of mitochondria in skeletal muscle of people with type 1 diabetes (T1D). These alterations are proposed to lead to decreased energy production in skeletal muscle during exercise and thus may contribute to the impaired aerobic exercise capacity reported in some people with T1D. This Symposium Review summarizes the evidence that similar alterations also occur in the mitochondria present in organ systems outside skeletal muscle in people with T1D, and that this may contribute to the development and progression of the known complications of T1D, which eventually lead to the reported premature mortality.
这篇综述的主题是什么？
1 型糖尿病患者各种器官系统中线粒体功能和/或形态受损的证据。
它强调了哪些进展？
线粒体功能和形态的损伤可能是 1 型糖尿病患者各种并发症病理生理学的主要机制。
我们最近观察到，1 型糖尿病（T1D）患者骨骼肌中线粒体的超微结构和功能存在显著改变。这些改变据推测会导致运动时骨骼肌中能量产生减少，因此可能导致一些 T1D 患者报告的有氧运动能力受损。本次专题综述总结了证据，表明 T1D 患者的骨骼肌外其他器官系统中存在的线粒体也存在类似的改变，这可能导致 T1D 的已知并发症的发展和进展，最终导致报告的过早死亡率。
