将 1 型糖尿病视为一种加速的肌肉衰老形式。
Considering Type 1 Diabetes as a Form of Accelerated Muscle Aging.
机构信息
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
出版信息
Exerc Sport Sci Rev. 2019 Apr;47(2):98-107. doi: 10.1249/JES.0000000000000184.
Recent evidence reveals impairments to skeletal muscle health in adolescent/young adults with type 1 diabetes (T1D). Interestingly, the observed changes in T1D are not unlike aged muscle, particularly, the alterations to mitochondria. Thus, we put forth the novel hypothesis that T1D may be considered a condition of accelerated muscle aging and that, similar to aging, mitochondrial dysfunction is a primary contributor to this complication.
最近的证据表明，1 型糖尿病（T1D）青少年/年轻成年人的骨骼肌健康受损。有趣的是，在 T1D 中观察到的变化与衰老肌肉并无不同，特别是线粒体的改变。因此，我们提出了一个新的假设，即 T1D 可能被认为是一种加速肌肉衰老的疾病，并且类似于衰老，线粒体功能障碍是导致这种并发症的主要原因。
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