Departament of Dentistry, School of Dentistry, Federal University of Pará.
Departament of Dentistry, School of Dentistry, University of São Paulo.
Dent Mater J. 2020 Mar 31;39(2):222-228. doi: 10.4012/dmj.2018-349. Epub 2019 Dec 11.
This study evaluated the osteogenic differentiation of human dental pulp stem cells in response to substances released by the pulp capping agents, Biodentine (BD), mineral trioxide aggregate (MTA) and two-paste calcium hydroxide cement (CHC), along with their physicochemical characteristics. The dimensional stability test showed that of the materials studied, only BD met the standards recommended by the International Organization for Standardization (ISO) for pulp capping materials and thus can be used safely. In the chemical tests, BD was the most stable material. In the Alizarin red S test, BD formed the higher amount of mineralized nodules in the mineralizing medium and also formed mineralized nodules in a non-mineralizing medium. BD releases substances that can significantly induce formation of the human dental pulp stem cell-mineralized extracellular matrix, with physicochemical characteristics that are more conducive to pulp repair than those of MTA and CHC.
本研究评估了人牙髓干细胞对牙髓盖髓剂释放物质的成骨分化反应，这些物质包括 Biodentine（BD）、矿物三氧化物聚合体（MTA）和双糊剂氢氧化钙水泥（CHC），以及它们的物理化学特性。尺寸稳定性测试表明，在所研究的材料中，只有 BD 符合国际标准化组织（ISO）推荐的牙髓盖髓材料标准，因此可以安全使用。在化学测试中，BD 是最稳定的材料。在茜素红 S 试验中，BD 在矿化介质中形成了更多的矿化结节，并且在非矿化介质中也形成了矿化结节。BD 释放的物质可以显著诱导人牙髓干细胞-矿化细胞外基质的形成，其理化特性比 MTA 和 CHC 更有利于牙髓修复。
