小麦生拟青霉中 terphenyl 衍生物和萜类化合物。

Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus.

机构信息

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

出版信息

J Antibiot (Tokyo). 2020 Mar;73(3):189-193. doi: 10.1038/s41429-019-0266-9. Epub 2019 Dec 11.

DOI:10.1038/s41429-019-0266-9

PMID:31827255

Abstract

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh(OCOCF)] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC value in the range from 17.9 to 46.3 μM. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC value of 47.7 μM. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 μM, respectively.

摘要

从曲霉属真菌 Aspergillus candidus 中分离得到一种新的 p-三联苯衍生物aspergucidusin A（1）、一种新的 cleistanthane 二萜 6-去氧aspergiloid C（13）和 12 种已知化合物（2-12 和 14）。通过 NMR 和 MS 数据的光谱分析阐明了新化合物的结构。通过[Rh(OCOCF)]络合物的圆二色性数据确定了 13 中 C-1 的绝对构型。化合物 2-8 和 11 对 K562 细胞系表现出中等抑制活性，IC 值范围为 17.9 至 46.3 μM。化合物 13 对 HepG2 细胞表现出中等细胞毒性，IC 值为 47.7 μM。化合物 11 和 12 对金黄色葡萄球菌的生长表现出中等活性，MIC 值分别为 6.25 μM。