聚羟基三联苯类化合物来自红树林内生真菌 LDJ-5。
Polyhydroxy -Terphenyls from a Mangrove Endophytic Fungus LDJ-5.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2021 Feb 2;19(2):82. doi: 10.3390/md19020082.
Six undescribed polyhydroxy -terphenyls, namely asperterphenyllins A-F, were isolated from an endophytic fungus LDJ-5. Their structures were determined by NMR and MS data. Differing from the previously reported -terphenyls, asperterphenyllin A represents the first -terphenyl dimer connected by a C-C bond. Asperterphenyllin A displayed anti-influenza virus A (H1N1) activity and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC values of 53 μM and 21 μM, respectively. The anti-influenza virus A (H1N1) activity and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of -terphenyls are reported for the first time. Asperterphenyllin G exhibited cytotoxicity against nine cell lines with IC values ranging from 0.4 to 1.7 μM. Asperterphenyllin C showed antimicrobial activity against species with a MIC value of 19 μg/mL.
从内生真菌 LDJ-5 中分离得到了六种未被描述的多羟基 - 三联苯，分别为 Asperterphenyllin A-F。通过 NMR 和 MS 数据确定了它们的结构。与之前报道的 - 三联苯不同，Asperterphenyllin A 代表了第一个通过 C-C 键连接的 - 三联苯二聚体。Asperterphenyllin A 表现出抗流感病毒 A (H1N1) 活性和蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制活性，IC 值分别为 53 μM 和 21 μM。这是首次报道 - 三联苯具有抗流感病毒 A (H1N1) 活性和蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制活性。Asperterphenyllin G 对 9 种细胞系表现出细胞毒性，IC 值范围为 0.4 至 1.7 μM。Asperterphenyllin C 对 种表现出抗菌活性，MIC 值为 19 μg/mL。
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