Laboratory of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, Mexico.
Universidad Autónoma de Nayarit, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n, Cd de la Cultura Amado Nervo, C.P, 63000 Tepic, Nayarit, Mexico.
Mediators Inflamm. 2019 Nov 19;2019:9130868. doi: 10.1155/2019/9130868. eCollection 2019.
Major depressive disorder (MDD) has a prevalence of 5% in adolescents. Several studies have described the association between the inflammatory response and MDD, but little is known about the relationship between MDD and growth factors, such as IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF. It must be appointed that there are scarce reports on growth factors in adolescents with MDD and even fewer with a clinical follow-up. In this work, we evaluated the levels of growth factors (IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF) in MDD adolescents and the clinical follow-up during eight weeks of treatment with fluoxetine. . All patients were diagnosed according to the DSM-IV-TR, and the severity of the symptoms was evaluated using the Hamilton Depression Rating Scale (HDRS). Growth factors IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF were quantified by cytometric bead array using serum samples from 22 adolescents with MDD and 18 healthy volunteers. . All patients showed clinical improvement since the fourth week of pharmacological treatment according to the HDRS. Considerably higher levels of IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF were detected in MDD adolescents as compared to healthy volunteers. A significant but temporal decrease was detected in basic FGF, G-CSF, and GM-CSF at week four of fluoxetine administration. . To the best of our knowledge, this is the first report to show alterations in the levels of growth factors, such as IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF in MDD adolescents during eight weeks of clinical follow-up. These disturbances might be involved in the physiopathology of MDD since such growth factors have been proven to participate in the neural development and correct functioning of the CNS; therefore, subtle alterations in it may contribute to MDD.
重度抑郁症（MDD）在青少年中的患病率为 5%。有几项研究描述了炎症反应与 MDD 之间的关系，但对于 MDD 与生长因子（如 IL-7、IL-9、IL-17A、VEGF、碱性成纤维细胞生长因子、G-CSF 和 GM-CSF）之间的关系知之甚少。必须指出的是，关于 MDD 青少年生长因子的报道很少，而具有临床随访的报道则更少。在这项工作中，我们评估了 MDD 青少年的生长因子（IL-7、IL-9、IL-17A、VEGF、碱性成纤维细胞生长因子、G-CSF 和 GM-CSF）水平，并在氟西汀治疗八周期间进行了临床随访。所有患者均根据 DSM-IV-TR 诊断，症状严重程度采用汉密尔顿抑郁评定量表（HDRS）评估。使用来自 22 名 MDD 青少年和 18 名健康志愿者的血清样本，通过细胞因子珠阵列定量分析生长因子 IL-7、IL-9、IL-17A、VEGF、碱性成纤维细胞生长因子、G-CSF 和 GM-CSF。所有患者在第四周开始药物治疗后临床状况均有改善，根据 HDRS 评估。与健康志愿者相比，MDD 青少年中检测到的 IL-7、IL-9、IL-17A、VEGF、碱性成纤维细胞生长因子、G-CSF 和 GM-CSF 水平明显更高。在氟西汀给药的第四周，检测到碱性成纤维细胞生长因子、G-CSF 和 GM-CSF 水平显著但暂时下降。据我们所知，这是第一项报道显示在 MDD 青少年中，在八周的临床随访期间，生长因子（如 IL-7、IL-9、IL-17A、VEGF、碱性成纤维细胞生长因子、G-CSF 和 GM-CSF）水平发生改变。这些紊乱可能与 MDD 的病理生理学有关，因为这些生长因子已被证明参与了神经发育和中枢神经系统的正常功能；因此，其细微改变可能会导致 MDD。
