Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, China.
Xiangya School of Medicine, Central South University, Changsha, Hunan Province 410013, China.
Oxid Med Cell Longev. 2019 Nov 19;2019:3214196. doi: 10.1155/2019/3214196. eCollection 2019.
Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection chain that protects against oxidative stress injury. This signaling axis regulates anti-inflammation and antioxidation by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis, apoptosis, alkaliptosis, and clockophagy. This review presents an overview of the role of the Nrf2/HO-1 signaling axis in the pathogenesis of pediatric respiratory diseases and the latest research progress on this subject. Overall, the Nrf2/HO-1 signaling axis has an important clinical value in pediatric respiratory diseases, and its protective effect needs further exploration.
呼吸系统疾病是临床实践中最常见的儿科疾病之一。因此，其发病机制、诊断和治疗值得进一步研究。核因子红细胞 2 相关因子 2/血红素加氧酶 1（Nrf2/HO-1）信号轴是一条多器官保护链，可防止氧化应激损伤。该信号轴通过调节钙离子、线粒体氧化应激、自噬、铁死亡、细胞焦亡、细胞凋亡、碱细胞自噬和生物钟自噬来调节抗炎和抗氧化作用。本综述介绍了 Nrf2/HO-1 信号轴在儿科呼吸系统疾病发病机制中的作用以及该领域的最新研究进展。总的来说，Nrf2/HO-1 信号轴在儿科呼吸系统疾病中具有重要的临床价值，其保护作用需要进一步探索。
