CD14 单核细胞是对 …… 反应中 CXCL10 的主要白细胞来源。
CD14 monocytes are the main leucocytic sources of CXCL10 in response to .
机构信息
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria3052, Australia.
The Department of Medical Biology, The University of Melbourne, Parkville, Victoria3010, Australia.
出版信息
Parasitology. 2020 Apr;147(4):465-470. doi: 10.1017/S0031182019001744. Epub 2019 Dec 13.
The CXCR3 chemokine CXCL10 or IFN-γ inducible protein 10 (IP-10) has been identified as an important biomarker of cerebral malaria (CM) mortality in children. Studies in mouse malaria infection models have shown that CXCL10 blockade alleviates brain intravascular inflammation and protects infected mice from CM. Despite the key role that CXCL10 plays in the development of CM, the leucocytic sources of CXCL10 in response to human malaria are not known. Here we investigated CXCL10 responses to Plasmodium falciparum in peripheral blood mononuclear cells (PBMCs). We found that PBMCs from malaria-unexposed donors produce CXCL10 in response to P. falciparum and that this response is IFN-γ-dependent. Moreover, CD14+ monocytes were identified as the main leucocytic sources of CXCL10 in peripheral blood, suggesting an important role for innate immune responses in the activation of this pathway involved in the development of symptomatic malaria.
趋化因子受体 3 配体 CXCL10 或干扰素-γ诱导蛋白 10（IP-10）已被确定为儿童脑型疟疾（CM）死亡的重要生物标志物。在鼠疟感染模型中的研究表明，CXCL10 阻断可减轻血管内脑炎症，并保护感染小鼠免受 CM 的侵害。尽管 CXCL10 在 CM 的发展中起着关键作用，但针对人类疟疾，白细胞中 CXCL10 的来源尚不清楚。在这里，我们研究了外周血单个核细胞（PBMCs）对恶性疟原虫的 CXCL10 反应。我们发现，来自未暴露于疟疾的供体的 PBMCs 会对恶性疟原虫产生 CXCL10，并且这种反应依赖于 IFN-γ。此外，CD14+单核细胞被鉴定为外周血中 CXCL10 的主要白细胞来源，这表明先天免疫反应在激活该途径中起着重要作用，该途径涉及症状性疟疾的发展。
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