Mussell Ashley, Frangou Costa, Zhang Jianmin
Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14261, USA.
Harvard TH Chan School of Public Health, Molecular and Integrative Physiological Sciences, Boston, MA 02115, USA.
Genes Dis. 2019 Jun 24;6(4):335-341. doi: 10.1016/j.gendis.2019.06.004. eCollection 2019 Dec.
Regulation of the Hippo signaling pathway is essential for normal organ growth and tissue homeostasis. The proteins that act to regulate this pathway are important for ensuring proper function and cellular location. Deubiquitinases (DUBs) are a family of proteases that act upon many proteins. While ubiquitinases add ubiquitin and target proteins for degradation, DUBs act by removing ubiquitin (Ub) moieties. Changes in ubiquitin chain topology results in the stabilization of proteins, membrane trafficking, and the alteration of cellular localization. While the roles of these proteins have been well established in a cancer setting, their convergence in cancer is still under investigation. In this review, we discuss the roles that DUBs play in the regulation of the Hippo signaling pathway for homeostasis and disease.
河马信号通路的调控对于正常器官生长和组织稳态至关重要。调控该通路的蛋白质对于确保正常功能和细胞定位很重要。去泛素化酶（DUBs）是一类作用于多种蛋白质的蛋白酶。泛素化酶添加泛素并将靶蛋白用于降解，而去泛素化酶则通过去除泛素（Ub）部分发挥作用。泛素链拓扑结构的变化导致蛋白质的稳定、膜运输以及细胞定位的改变。虽然这些蛋白质在癌症环境中的作用已得到充分证实，但其在癌症中的汇聚情况仍在研究中。在本综述中，我们讨论了去泛素化酶在调控河马信号通路以维持稳态和疾病方面所起的作用。
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