Lefemine A, Acuff R, Vo N, Waycaster M
Department of Surgery, Veterans Administration Medical Center, Johnson City, Tennessee 37684.
J Am Coll Nutr. 1988 Oct;7(5):355-9. doi: 10.1080/07315724.1988.10720252.
Two hundred patients assessed for nutritional deficiencies were analyzed for reaction to skin testing with common antigens and the incidence of sepsis and death. Only 39% of all skin tests were positive, though 50% of the patients had at least one positive test. Associated diagnoses revealed a high incidence of malnutrition, cancer, radiation therapy, and chemotherapy. Analysis using Chi-square and Gamma shows good statistical correlation between skin tests and sepsis and death. Those with negative tests (anergic) using PPD, Candida, and mumps had a threefold higher mortality. Major sepsis also increased in the skin negative group (+80%), but here the incidence varied directly with the number of positive skin tests. Mortality, unlike sepsis, was influenced only by the presence of delayed hypersensitivity and was not related to the number of positive reactions. The basic rate of infection or mortality was not influenced by major surgery.
对200名评估营养缺乏情况的患者进行分析，以了解其对常见抗原皮肤试验的反应以及败血症和死亡的发生率。尽管50%的患者至少有一项阳性试验，但所有皮肤试验中只有39%呈阳性。相关诊断显示营养不良、癌症、放射治疗和化疗的发生率很高。使用卡方检验和伽马检验分析表明，皮肤试验与败血症和死亡之间存在良好的统计相关性。使用结核菌素纯蛋白衍生物（PPD）、念珠菌和腮腺炎进行试验呈阴性（无反应性）的患者死亡率高出三倍。皮肤试验阴性组的严重败血症发生率也有所增加（+80%），但此处发生率与阳性皮肤试验的数量呈直接变化关系。与败血症不同，死亡率仅受迟发型超敏反应的影响，与阳性反应的数量无关。重大手术并未影响感染或死亡率的基本发生率。
