Miyake A, Ikegami M, Chen C F, Arita N, Aono T, Tanizawa O, Yoshikawa T
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
J Endocrinol Invest. 1988 May;11(5):383-4. doi: 10.1007/BF03349060.
To determine the incidence of hyperprolactinemia and prolactinoma without symptoms in men, the serum levels of prolactin were measured in 4803 men. Of these, 14 had hyperprolactinemia with prolactin level of over 50 ng/ml, and 3 had prolactin levels of more than 500 ng/ml. Of these 3 subjects, 2 were found to have pituitary prolactinoma by computed tomograph scanning and surgery, the other subject, who was highly suspected to have prolactinoma, refused further examinations. The serum prolactin levels of 51-100 ng/ml in 11 subjects may have been induced by drugs (sulpiride) or unknown factors. The present survey suggests that the incidence of prolactinoma in men in the general population might be estimated to be 1:1600, and that mass screening is useful for early diagnosis of asymptomatic prolactinoma.
为确定男性无症状高泌乳素血症和泌乳素瘤的发病率，对4803名男性进行了血清泌乳素水平检测。其中，14人患有高泌乳素血症，泌乳素水平超过50 ng/ml，3人泌乳素水平超过500 ng/ml。在这3名受试者中，2人经计算机断层扫描和手术发现患有垂体泌乳素瘤，另一名高度怀疑患有泌乳素瘤的受试者拒绝进一步检查。11名受试者血清泌乳素水平为51 - 100 ng/ml，可能是由药物（舒必利）或未知因素引起。本次调查表明，普通人群中男性泌乳素瘤的发病率估计可能为1:1600，且大规模筛查有助于无症状泌乳素瘤的早期诊断。
