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普通人群中的无症状高泌乳素血症和泌乳素瘤——通过血清泌乳素配对检测进行大规模筛查

Asymptomatic hyperprolactinaemia and prolactinoma in the general population--mass screening by paired assays of serum prolactin.

作者信息

Miyai K, Ichihara K, Kondo K, Mori S

出版信息

Clin Endocrinol (Oxf). 1986 Nov;25(5):549-54. doi: 10.1111/j.1365-2265.1986.tb03608.x.

DOI:10.1111/j.1365-2265.1986.tb03608.x
PMID:3621622
Abstract

A total of 10,550 'normal' adults (8450 men and 2100 women) in the general population were screened by a paired assay method for serum PRL and 40 subjects with hyperprolactinaemia (greater than 75 micrograms/l) were detected. Of these, five patients (three men and two women) with pituitary prolactinoma, one man with empty sella syndrome, 10 cases of 'big' prolactinaemia, seven pregnant women and 13 subjects with drug-induced hyperprolactinaemia were found. The patients with prolactinoma had few if any complaints (asymptomatic prolactinoma).

摘要

采用配对检测法对普通人群中总共10550名“正常”成年人(8450名男性和2100名女性)进行血清催乳素筛查,检测出40名高催乳素血症患者(大于75微克/升)。其中,发现5例垂体催乳素瘤患者(3名男性和2名女性),1例空蝶鞍综合征男性患者,10例“大”催乳素血症患者,7名孕妇以及13名药物性高催乳素血症患者。催乳素瘤患者几乎没有任何症状(无症状催乳素瘤)。

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Asymptomatic hyperprolactinaemia and prolactinoma in the general population--mass screening by paired assays of serum prolactin.普通人群中的无症状高泌乳素血症和泌乳素瘤——通过血清泌乳素配对检测进行大规模筛查
Clin Endocrinol (Oxf). 1986 Nov;25(5):549-54. doi: 10.1111/j.1365-2265.1986.tb03608.x.
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Mass screening for hyperprolactinemia and prolactinoma in men.男性高催乳素血症和催乳素瘤的大规模筛查。
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[Detection of asymptomatic prolactinoma by a mass screening program].
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[The value of functional tests in diagnosis of prolactinoma].[功能测试在泌乳素瘤诊断中的价值]
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Pituitary. 2020 Apr;23(2):120-128. doi: 10.1007/s11102-019-01008-z.
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Genesis of prolactinomas: studies using estrogen-treated animals.催乳素瘤的起源:使用雌激素处理动物的研究
Front Horm Res. 2006;35:32-49. doi: 10.1159/000094307.
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Prolactinomas and pregnancy.催乳素瘤与妊娠
Pituitary. 2005;8(1):31-8. doi: 10.1007/s11102-005-5083-4.
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Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains.雌激素诱导垂体肿瘤发生的遗传基础:在ACI和哥本哈根大鼠品系的正反交中确定决定雌激素诱导垂体生长的基因座。
Genetics. 2005 Apr;169(4):2189-97. doi: 10.1534/genetics.104.039370. Epub 2005 Jan 31.
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Hyperprolactinemia in asymptomatic patients is related to high molecular weight posttranslational variants or glycosylated forms.
Pituitary. 2002;5(4):255-60. doi: 10.1023/a:1025381917677.
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Unmodified prolactin (PRL) promotes PRL secretion and acidophil hypertrophy and is associated with pituitary hyperplasia in female rats.
Endocrine. 2003 Feb-Mar;20(1-2):101-10. doi: 10.1385/ENDO:20:1-2:101.
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Estrogen action in the regulation of cell proliferation, cell survival, and tumorigenesis in the rat anterior pituitary gland.雌激素在大鼠垂体前叶细胞增殖、细胞存活和肿瘤发生调节中的作用。
Endocrine. 1999 Dec;11(3):217-33. doi: 10.1385/ENDO:11:3:217.
8
Mass screening for hyperprolactinemia and prolactinoma in men.男性高催乳素血症和催乳素瘤的大规模筛查。
J Endocrinol Invest. 1988 May;11(5):383-4. doi: 10.1007/BF03349060.
9
Hyperprolactinaemia.高催乳素血症
BMJ. 1988 Sep 17;297(6650):701-2. doi: 10.1136/bmj.297.6650.701.