Ngolab Jennifer, Honma Patrick, Rissman Robert A
Department of Neurosciences, University of California, San Diego, CA, USA.
Neuroscience Graduate Program, University of California, San Francisco, CA, USA.
Neurol Ther. 2019 Dec;8(Suppl 2):57-72. doi: 10.1007/s40120-019-00173-4. Epub 2019 Dec 12.
As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest in the retina as a means to assess the state of the AD brain. The development and refinement of ophthalmologic techniques for studying the retina in vivo have produced evidence of retinal degeneration in AD diagnosed patients. In this review, we will discuss retinal imaging techniques implemented to study the changes in AD retina as well as highlight the recent efforts made to correlate such findings to other clinical hallmarks of AD to assess the viability of the retina as a biomarker for AD.
作为中枢神经系统的一部分，视网膜可能反映生理过程以及与脑部疾病相关的异常情况。事实上，人们已经齐心协力去了解阿尔茨海默病（AD）的病理变化如何在视网膜中表现出来，以此作为评估AD脑部状态的一种手段。用于在体内研究视网膜的眼科技术的发展与完善，已经在被诊断为AD的患者中产生了视网膜退化的证据。在这篇综述中，我们将讨论为研究AD视网膜变化而采用的视网膜成像技术，并着重介绍最近为将这些发现与AD的其他临床特征相关联所做的努力，以评估视网膜作为AD生物标志物的可行性。
