2018 年曼谷西南部暴发疫情中分离的基孔肯雅病毒分离株的基因组序列。
Genome sequences of chikungunya virus isolates from an outbreak in southwest Bangkok in 2018.
机构信息
Department of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn University, Bangkok, 10330, Thailand.
Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Arch Virol. 2020 Feb;165(2):445-450. doi: 10.1007/s00705-019-04509-1. Epub 2019 Dec 13.
An outbreak of chikungunya virus (CHIKV) infection occurred in southwest Bangkok during the 2018 rainy season. The envelope glycoprotein E1 gene sequence of the infecting strain belonged to an East/Central/South African lineage with alanine at residue 226. Mutations in the predicted E1 (K211E) and E2 (V264A) proteins of CHIKV were identified in CHIKV-infected patients and in an Aedes aegypti mosquito. Analysis of the complete genome sequences showed marked differences from the strains causing previous outbreaks in Thailand in 2008-2009 and 2013 but showed similarities to strains from more recent CHIKV outbreaks in South and Southeast Asia.
2018 年雨季，曼谷西南部爆发了基孔肯雅热病毒（CHIKV）感染疫情。感染株的包膜糖蛋白 E1 基因序列属于东/中非/南非谱系，其 226 位残基为丙氨酸。在感染 CHIKV 的患者和埃及伊蚊中鉴定出 CHIKV 中 E1（K211E）和 E2（V264A）蛋白的突变。对完整基因组序列的分析表明，与 2008-2009 年和 2013 年泰国之前的疫情爆发的菌株有明显差异，但与最近南亚和东南亚的 CHIKV 疫情爆发的菌株相似。
Zotero 插件