Laboratory of Pharmacology, Neurobiology and Behavior (URAC-37), Cadi Ayyad University, Marrakech, Morocco; Laboratory of Bioorganic and Macromolecular Chemistry. Cadi Ayyad University, Faculty of Sciences and Techniques, Marrakech, Morocco.
Laboratory of Pharmacology, Neurobiology and Behavior (URAC-37), Cadi Ayyad University, Marrakech, Morocco.
Environ Toxicol Pharmacol. 2020 Feb;74:103309. doi: 10.1016/j.etap.2019.103309. Epub 2019 Nov 27.
The present study has investigated developmental neurotoxicity of Metam sodium (MS), from gestational day 6 and throughout the gestation period until delivery. Therefore, mated female mice were orally exposed on a daily basis to 0 (control), 50, 100 or 150 mg of MS/kg of body weight and their standard fertility and reproductive parameters were assessed. The offspring were examined for their sensorimotor development, depression and cognitive performance. Our results showed that MS exposure during pregnancy led to one case of mortality, two cases of abortion and disturbed fertility and reproductive parameters in pregnant dams. In offspring, MS induced an overall delay in innate reflexes and sensorimotor performances. Furthermore, all prenatally treated animals showed an increased level of depression-like behavior as well as a pronounced cognitive impairment in adulthood. These results demonstrated that prenatal exposure to MS causes a long-lasting developmental neurotoxicity and alters a wide range of behavioral functions in mice.
本研究调查了甲磺隆（MS）的发育神经毒性，从妊娠第 6 天到整个妊娠期直至分娩。因此，将交配的雌性小鼠每日口服暴露于 0（对照）、50、100 或 150 mg MS/kg 体重，并评估其标准生育和生殖参数。检查后代的感觉运动发育、抑郁和认知表现。我们的结果表明，怀孕期间暴露于 MS 导致 1 例死亡、2 例流产以及怀孕母鼠的生育力和生殖参数受到干扰。在后代中，MS 导致先天反射和感觉运动表现整体延迟。此外，所有产前处理的动物都表现出抑郁样行为增加以及成年后认知功能明显受损。这些结果表明，产前暴露于 MS 会导致长期的发育神经毒性，并改变小鼠的广泛行为功能。
