Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Cadi Ayyad University, Faculty of Sciences, Marrakech, Morocco; Research Laboratory for Sustainable Development and Health, Cadi Ayyad University, Faculty of Sciences and Techniques, Marrakech, Morocco.
Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Cadi Ayyad University, Faculty of Sciences, Marrakech, Morocco.
Environ Toxicol Pharmacol. 2021 Jul;85:103630. doi: 10.1016/j.etap.2021.103630. Epub 2021 Mar 9.
Metam sodium (MS) is a widespread biocide with a broad-spectrum activity. Here, we addressed the behavioral impact of MS by exposing female mice to 50, 100 and 150 mg/kg of MS during both pregnancy and lactation, and evaluated the oxidative stress as a potential mechanism of MS-induced neurotoxicity. The results showed that MS affected fertility and reproduction parameters as well as some aspects of maternal behavior, especially at high doses. In offspring, MS caused a significant delay in the ontogeny of sensorimotor functions. In addition, treated mice exhibited during adulthood an increase of anxiety-like, depression-like behaviors as well as learning and memory impairment. These alterations were accompanied by an increase of the superoxide dismutase activity, and a significant decreased catalase and malondialdehyde activities in specific brain areas. The present work revealed that early exposure to MS induced sensorimotor and behavioral impairments in offspring likely associated with onset of oxidative stress.
甲脒亚甲基（MS）是一种广泛使用的杀菌剂，具有广谱活性。在这里，我们通过在妊娠和哺乳期暴露于 50、100 和 150mg/kg 的 MS 来研究 MS 对行为的影响，并评估氧化应激作为 MS 诱导的神经毒性的潜在机制。结果表明，MS 影响生育力和繁殖参数以及某些母性行为方面，尤其是在高剂量下。在后代中，MS 导致感觉运动功能的发育明显延迟。此外，经处理的小鼠在成年期表现出焦虑样、抑郁样行为以及学习和记忆障碍增加。这些变化伴随着特定脑区中超氧化物歧化酶活性的增加，以及过氧化氢酶和丙二醛活性的显著降低。本研究表明，早期接触 MS 会导致后代出现感觉运动和行为障碍，可能与氧化应激的发生有关。
