Kaikai Nour-Eddine, Ba-M Hamed Saadia, Slimani Aiman, Dilagui Ilham, Hanchi Asmae Lamrani, Soraa Nabila, Mezrioui Nour-Eddine, Bennis Mohamed, Ghanima Abderrazzak
Laboratory of Pharmacology, Neurobiology, Anthropology, and Environment, Cadi Ayyad University, Faculty of Sciences, Marrakesh, Morocco; Research Laboratory for Sustainable Development and Health. Cadi Ayyad University, Faculty of Sciences and Techniques, Marrakesh, Morocco.
Laboratory of Pharmacology, Neurobiology, Anthropology, and Environment, Cadi Ayyad University, Faculty of Sciences, Marrakesh, Morocco.
Environ Toxicol Pharmacol. 2023 Mar;98:104066. doi: 10.1016/j.etap.2023.104066. Epub 2023 Jan 11.
Metam sodium-based pesticide (MS-BP) is widely used in agriculture and public health. We have previously demonstrated that maternal exposure to MS-BP resulted in sensorimotor alterations in mice offspring with long-lasting deficits including anxiety- and depression-like behaviors. Here, we project to verify whether these two neurobehavioral effects occur during adulthood following direct exposure to MS-BP and whether it results in changes in the serotoninergic system and gut microbiota. Our findings showed that chronic exposure to MS-BP increased anxiety- and depression-like behaviors, accompanied by a depletion of serotonin-like neurons within the dorsal raphe nucleus and a reduction in serotoninergic terminals in the infralimbic cortex and the basolateral amygdala. In addition, all MS-BP-exposed animals exhibited a reduced total bacterial number and diversity of gut microbiota. Taken together, our data demonstrated that MS-BP-induced behavioral changes could be related to the impairment of the serotoninergic system and gut microbiota dysbiosis.
甲拌磷钠基农药（MS-BP）广泛应用于农业和公共卫生领域。我们之前已经证明，母体接触MS-BP会导致小鼠后代出现感觉运动改变，并伴有长期缺陷，包括焦虑和抑郁样行为。在此，我们计划验证直接接触MS-BP后，这两种神经行为效应是否在成年期出现，以及它是否会导致血清素能系统和肠道微生物群的变化。我们的研究结果表明，长期接触MS-BP会增加焦虑和抑郁样行为，同时伴有中缝背核内5-羟色胺样神经元的减少以及边缘下皮质和基底外侧杏仁核中5-羟色胺能终末的减少。此外，所有接触MS-BP的动物肠道微生物群的细菌总数和多样性均降低。综上所述，我们的数据表明，MS-BP诱导的行为变化可能与血清素能系统的损伤和肠道微生物群失调有关。
