Molecular Mechanisms of Antibiotics, Division of Life Science, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Division of Applied Life Science (BK21plus Program), Gyeongsang National University, Jinju 52828, Korea.
Molecules. 2019 Dec 10;24(24):4511. doi: 10.3390/molecules24244511.
is a rapid-growing, multidrug-resistant, non-tuberculous mycobacterial species responsible for a variety of human infections, such as cutaneous and pulmonary infections. infections are very difficult to eradicate due to the natural and acquired multidrug resistance profiles of . Thus, there is an urgent need for the development of effective drugs or regimens against infections. Here, we report the activity of a US Food and Drug Administration approved drug, thiostrepton, against . We found that thiostrepton significantly inhibited the growth of wild-type strains, subspecies, clinical isolates, and drug-resistant mutants in vitro and in macrophages. In addition, treatment of macrophages with thiostrepton significantly decreased proinflammatory cytokine production in a dose-dependent manner, suggesting an inhibitory effect of thiostrepton on inflammation induced during infection. We further showed that thiostrepton exhibits antimicrobial effects in vivo using a zebrafish model of infection.
是一种快速生长、多药耐药、非结核分枝杆菌物种，可导致多种人类感染，如皮肤和肺部感染。由于 的天然和获得性多药耐药谱， 感染很难根除。因此，迫切需要开发针对 感染的有效药物或方案。在这里，我们报告了一种美国食品和药物管理局批准的药物硫链丝菌素对 的活性。我们发现硫链丝菌素在体外和巨噬细胞中显著抑制 野生型菌株、亚种、临床分离株和耐药突变株的生长。此外，用硫链丝菌素处理巨噬细胞可显著地、剂量依赖性地减少促炎细胞因子的产生，表明硫链丝菌素对 感染引起的炎症有抑制作用。我们进一步利用 感染的斑马鱼模型显示，硫链丝菌素具有体内的抗菌作用。
