Tokarska Kamila, Majsterek Ireneusz, Cuchra Magda, Woźniacka Anna
Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Lodz, Poland.
Postepy Dermatol Alergol. 2019 Oct;36(5):513-518. doi: 10.5114/ada.2019.85251. Epub 2019 Nov 12.
Systemic lupus erythematosus is a chronic autoimmune disease connected with complex and unclear disorders of the immune system, which causes inflammation of body tissues and internal organs. It leads to the formation of anti-nuclear antibodies (ANA) and immune complexes. Numerous immune system disorders and dysfunctions in the biochemical processes can occur in the course of the disease, and a wide range of abnormalities associated with cellular respiratory processes and mitochondrial function have been documented. The following paper presents the current understanding of the contribution of these disorders to the pathogenesis of lupus.
系统性红斑狼疮是一种慢性自身免疫性疾病，与复杂且不明的免疫系统紊乱相关，可导致身体组织和内脏器官发生炎症。它会引发抗核抗体（ANA）和免疫复合物的形成。在疾病过程中，可能会出现众多免疫系统紊乱以及生化过程中的功能障碍，并且已经记录到与细胞呼吸过程和线粒体功能相关的广泛异常情况。以下论文阐述了目前对这些紊乱在狼疮发病机制中所起作用的理解。
