Albinsson Bo, Rönnberg Bengt, Vene Sirkka, Lundkvist Åke
Department of Medical Biochemistry and Microbiology, Zoonosis Science Centre, Uppsala University, Uppsala, Sweden.
Laboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden.
Infect Ecol Epidemiol. 2019 Dec 3;9(1):1696132. doi: 10.1080/20008686.2019.1696132. eCollection 2019.
We report a new tool for improved serological diagnostics in suspected tick-borne encephalitis (TBE) vaccine failure cases. Due to an increase in the incidence of disease as well as the number of vaccinees, specific and simplified diagnostic methods are needed. Antibody responses to TBE-virus (TBEV) non-structural protein 1 (NS1) are detectable post TBEV infection but not post vaccination. We have used samples from 14 previously confirmed Swedish TBEV vaccine failure patients to study antibody responses against NS1 and whole virus antigens, respectively. Our conclusion is that the detection of antibodies directed to TBEV NS1 antigen is a useful tool to considerably simplify and improve the quality in investigations regarding suspected TBEV infection in vaccinated patients.
我们报告了一种新工具，用于改善疑似蜱传脑炎（TBE）疫苗接种失败病例的血清学诊断。由于疾病发病率以及接种疫苗人数的增加，需要特异性且简化的诊断方法。感染TBE病毒（TBEV）后可检测到针对非结构蛋白1（NS1）的抗体反应，但接种疫苗后则检测不到。我们使用了来自14名先前确诊的瑞典TBEV疫苗接种失败患者的样本，分别研究针对NS1和全病毒抗原的抗体反应。我们的结论是，检测针对TBEV NS1抗原的抗体是一种有用的工具，可显著简化并提高对接种疫苗患者疑似TBEV感染调查的质量。
